Gasiorowski Kazimierz, Steciwko Andrzej, Grata-Borkowska Urszula, Drobnik Jarosław
Department of Basic Medical Sciences, Wrocław Medical University, Kochanowskiego 14, 51-601 Wrocław, Poland.
Cell Mol Biol Lett. 2004;9(2):389-99.
Lymphocytes were obtained by heart-punction from rats bearing Morris hepatoma. In the short term, 18-hour cultures of these lymphocytes exhibited a significantly higher amount of apoptotic cells than lymphocyte cultures from the healthy, control animals. Neuraminidase, injected into the caudal vein of the rats with Morris hepatoma, caused a marked lowering in the amount of apoptotic blood-lymphocytes and an elevation of the amount of viable cells. The possible mechanism of neuraminidase preventing the apoptosis of blood-circulating lymphocytes in tumour hosts is discussed herein.
通过心脏穿刺从患有莫里斯肝癌的大鼠中获取淋巴细胞。短期内，这些淋巴细胞进行18小时培养后，与来自健康对照动物的淋巴细胞培养物相比，其凋亡细胞数量显著更高。将神经氨酸酶注入患有莫里斯肝癌的大鼠尾静脉后，血液淋巴细胞的凋亡数量显著降低，活细胞数量增加。本文讨论了神经氨酸酶阻止肿瘤宿主血液循环中淋巴细胞凋亡的可能机制。
