Lorée S, Dompmartin A, Penven K, Harel D, Leroy D
Department of Dermatology, University Hospital, Caen, France.
J Wound Care. 2004 Jun;13(6):249-52. doi: 10.12968/jowc.2004.13.6.26629.
Between May 2001 and October 2002 a prospective controlled open non-comparative study was performed to assess the effectiveness of topical negative pressure in the fibrinous debridement of chronic leg ulcers.
Fifteen leg ulcers that had not responded to several other treatment modalities were treated with the Vacuum Assisted Closure system (KCI) for six days.
The median percentage reduction in fibrinous tissue was 28% on day three and 40% on day six. Between days one and three the percentage change was > or = 50% in four patients and > or = 25% in six patients. Between days three and six percentages of fibrin in the wound were lower in all patients, except for two who had higher percentages and two who had the same percentage.
VAC therapy was rapidly efficacious, promoting angiogenesis and the formation of healthy tissue.
在2001年5月至2002年10月期间，开展了一项前瞻性对照开放非比较性研究，以评估局部负压在慢性腿部溃疡纤维蛋白清创中的有效性。
对15例对其他几种治疗方式均无反应的腿部溃疡，采用真空辅助闭合系统（KCI）治疗6天。
第3天纤维蛋白组织减少的中位数百分比为28%，第6天为40%。在第1天至第3天期间，4例患者的百分比变化≥50%，6例患者的百分比变化≥25%。在第3天至第6天期间，除2例患者纤维蛋白百分比升高和2例患者纤维蛋白百分比不变外，所有患者伤口中的纤维蛋白百分比均降低。
负压封闭引流疗法迅速有效，可促进血管生成和健康组织形成。
