Mendonca Derick A, Papini Remo, Price Patricia E
Regional West Midlands Burns Centre, Burns and Plastic Surgery Department, Selly Oak Hospital, Birmingham, UK.
Int Wound J. 2006 Dec;3(4):261-71. doi: 10.1111/j.1742-481X.2006.00266.x.
Topical negative pressure (TNP) is a mode of therapy used to encourage wound healing. It can be used as a primary treatment for chronic/complex wounds or as an adjunct to surgery. Based on the evidence to date, the clinical effectiveness of negative-pressure therapy is still unclear. Although case reports and retrospective studies have demonstrated enhanced wound healing in acute/traumatic wounds, chronic wounds, infected wounds, wounds secondary to diabetes mellitus, sternal wounds and lower limb wounds, there are very few randomised controlled trials, with unclear results. The evidence is lacking for the use of TNP therapy for other indications to enhance wound healing such as patients with decubitus ulcers, diabetes and peripheral vascular disease and to improve skin graft take. There have been, as yet, no quality-of-life studies available for negative-pressure therapy. Despite this, the usage of TNP has increased. This review provides an overview of clinical studies using TNP and proposes avenues for further research to elucidate the exact mechanism of TNP, in addition to large randomised controlled clinical trials of patients undergoing this therapy.
局部负压（TNP）是一种用于促进伤口愈合的治疗方式。它可作为慢性/复杂伤口的主要治疗方法，或作为手术的辅助手段。根据目前的证据，负压治疗的临床效果仍不明确。尽管病例报告和回顾性研究表明，负压治疗可促进急性/创伤性伤口、慢性伤口、感染伤口、糖尿病继发伤口、胸骨伤口和下肢伤口的愈合，但随机对照试验很少，结果也不明确。缺乏证据表明TNP疗法用于其他适应症（如压疮、糖尿病和外周血管疾病患者）以促进伤口愈合以及提高皮肤移植成活率。目前尚无关于负压治疗的生活质量研究。尽管如此，TNP的使用仍在增加。本综述概述了使用TNP的临床研究，并提出了进一步研究的途径，以阐明TNP的确切机制，此外还需对接受该治疗的患者进行大型随机对照临床试验。
