已批准药物和新型药物与拟青霉属菌种的体外相互作用
In vitro interactions of approved and novel drugs against Paecilomyces spp.
作者信息
Ortoneda Montserrat, Capilla Javier, Pastor F Javier, Pujol Isabel, Yustes Clara, Serena Carolina, Guarro Josep
机构信息
Unitat de Microbiologia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain.
出版信息
Antimicrob Agents Chemother. 2004 Jul;48(7):2727-9. doi: 10.1128/AAC.48.7.2727-2729.2004.
Abstract
We have evaluated the in vitro activity of 15 combinations of antifungal drugs (amphotericin B, itraconazole, voriconazole, albaconazole, ravuconazole, terbinafine, and micafungin) against four isolates of Paecilomyces variotii and three of P. lilacinus. The interaction of terbinafine with the four azoles was synergistic for 53% of the combinations, while the interactions of both amphotericin B and micafungin with the rest of antifungal agents were mainly indifferent.
摘要
我们评估了15种抗真菌药物组合（两性霉素B、伊曲康唑、伏立康唑、阿巴康唑、雷夫康唑、特比萘芬和米卡芬净）对4株变幻青霉和3株淡紫拟青霉的体外活性。特比萘芬与4种唑类药物的组合中，53%呈现协同作用，而两性霉素B和米卡芬净与其他抗真菌药物的相互作用主要为无关作用。
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