Ying Xiaomin, Luo Hong, Luo Jingchu, Li Wuju
Beijing Institute of Basic Medical Sciences, PO Box 130(3), Beijing 100850, People's Republic of China.
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W150-3. doi: 10.1093/nar/gkh445.
Prediction of RNA secondary structure is important in the functional analysis of RNA molecules. The RDfolder web server described in this paper provides two methods for prediction of RNA secondary structure: random stacking of helical regions and helical regions distribution. The random stacking method predicts secondary structure by Monte Carlo simulations. The method of helical regions distribution predicts secondary structure based on the helices that appear most frequently in the set of structures, which are generated by the random stacking method. The RDfolder web server can be accessed at http://rna.cbi.pku.edu.cn.
RNA二级结构预测在RNA分子的功能分析中很重要。本文所述的RDfolder网络服务器提供了两种预测RNA二级结构的方法：螺旋区域的随机堆积和螺旋区域分布。随机堆积方法通过蒙特卡罗模拟预测二级结构。螺旋区域分布方法基于随机堆积方法生成的结构集中出现频率最高的螺旋来预测二级结构。可通过http://rna.cbi.pku.edu.cn访问RDfolder网络服务器。
