CARNAC：相关RNA的折叠家族
CARNAC: folding families of related RNAs.
作者信息
Touzet Hélène, Perriquet Olivier
机构信息
Laboratoire d'Informatique Fondamentale de Lille, UMR CNRS 8022, Université des Sciences et Technologies de Lille, France.
出版信息
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W142-5. doi: 10.1093/nar/gkh415.
Abstract
We present a tool for the prediction of conserved secondary structure elements of a family of homologous non-coding RNAs. Our method does not require any prior multiple sequence alignment. Thus, it successfully applies to datasets with low primary structure similarity. The functionality is demonstrated using three example datasets: sequences of RNase P RNAs, ciliate telomerases and enterovirus messenger RNAs. CARNAC has a web server that can be accessed at the URL http://bioinfo.lifl.fr/carnac.
摘要
我们提出了一种用于预测同源非编码RNA家族保守二级结构元件的工具。我们的方法不需要任何预先的多序列比对。因此，它成功应用于一级结构相似性低的数据集。使用三个示例数据集展示了该功能：核糖核酸酶P RNA、纤毛虫端粒酶和肠道病毒信使RNA的序列。CARNAC有一个网络服务器，可通过网址http://bioinfo.lifl.fr/carnac访问。
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