dbMHC的基于测序的分型工具：对高度多态性基因序列进行分型。
The sequencing-based typing tool of dbMHC: typing highly polymorphic gene sequences.
作者信息
Helmberg Wolfgang, Dunivin Raymond, Feolo Michael
机构信息
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 45, 8600 Rockville Pike, Bethesda, MD 20894, USA.
出版信息
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W173-5. doi: 10.1093/nar/gkh424.
Abstract
The dbMHC resource (http://www.ncbi.nlm.nih.gov/mhc/sbt.cgi?cmd=main) at the National Center for Biotechnology Information (NCBI) has developed an online tool for evaluating the allelic composition of sequencing-based typing (SBT) results of cDNA or genomic sequences. Whether the samples are heterozygous, haploid or a combination of the two, they can be compared with two up-to-date databases of all known alleles of several human leukocyte antigen (HLA) and killer cell immunoglobulin-like receptor (KIR) loci. The results of the submission are returned as a table of potential allele hits, along with the respective base changes and an interactive sequence viewer for close examination of the alignment.
相似文献
1
The sequencing-based typing tool of dbMHC: typing highly polymorphic gene sequences.dbMHC的基于测序的分型工具：对高度多态性基因序列进行分型。
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W173-5. doi: 10.1093/nar/gkh424.
2
Cloning and sequencing alleles of the KIR2DL4 gene from genomic DNA samples.从基因组DNA样本中克隆和测序KIR2DL4基因的等位基因。
Tissue Antigens. 2007 Apr;69 Suppl 1:88-91. doi: 10.1111/j.1399-0039.2006.762_2.x.
3
Detailed gene and allele content analysis of three homozygous KIR haplotypes.三种纯合KIR单倍型的详细基因和等位基因含量分析。
Tissue Antigens. 2006 Jul;68(1):72-7. doi: 10.1111/j.1399-0039.2006.00606.x.
4
An update of the HLA genomic region, locus information and disease associations: 2004.HLA基因组区域、基因座信息及疾病关联的最新情况：2004年。
Tissue Antigens. 2004 Dec;64(6):631-49. doi: 10.1111/j.1399-0039.2004.00327.x.
5
SNP-VISTA: an interactive SNP visualization tool.SNP-VISTA：一种交互式单核苷酸多态性可视化工具。
BMC Bioinformatics. 2005 Dec 8;6:292. doi: 10.1186/1471-2105-6-292.
6
A community standard XML message format for sequencing-based typing data.一种用于基于测序的分型数据的社区标准XML消息格式。
Tissue Antigens. 2007 Apr;69 Suppl 1:69-71. doi: 10.1111/j.1399-0039.2006.76061.x.
7
Genetic diversity of KIR natural killer cell markers in populations from France, Guadeloupe, Finland, Senegal and Réunion.法国、瓜德罗普岛、芬兰、塞内加尔和留尼汪人群中杀伤细胞免疫球蛋白样受体自然杀伤细胞标志物的遗传多样性。
Tissue Antigens. 2005 Oct;66(4):267-76. doi: 10.1111/j.1399-0039.2005.00473.x.
8
Bioinformatics: analysis of HLA sequence data.生物信息学：HLA序列数据分析
Rev Immunogenet. 2000;2(4):492-517.
9
Comprehensive approach to high-resolution KIR typing.高分辨率KIR分型的综合方法。
Hum Immunol. 2007 Sep;68(9):789-96. doi: 10.1016/j.humimm.2007.07.002. Epub 2007 Aug 1.
10
The IMGT/HLA sequence database.国际免疫遗传学信息系统/HLA序列数据库
Rev Immunogenet. 2000;2(4):518-31.
引用本文的文献
1
A Peptide Vaccine Candidate Tailored to Individuals' Genetics Mimics the Multi-Targeted T Cell Immunity of COVID-19 Convalescent Subjects.一种根据个体基因定制的肽疫苗候选物模拟了新冠康复者的多靶点T细胞免疫。
Front Genet. 2021 Jun 23;12:684152. doi: 10.3389/fgene.2021.684152. eCollection 2021.
2
Computationally Optimized SARS-CoV-2 MHC Class I and II Vaccine Formulations Predicted to Target Human Haplotype Distributions.基于计算优化的 SARS-CoV-2 MHC Ⅰ类和Ⅱ类疫苗配方，预测针对人类单倍型分布。
Cell Syst. 2020 Aug 26;11(2):131-144.e6. doi: 10.1016/j.cels.2020.06.009. Epub 2020 Jul 27.
3
Database resources of the National Center for Biotechnology Information.美国国立生物技术信息中心的数据库资源。
Nucleic Acids Res. 2016 Jan 4;44(D1):D7-19. doi: 10.1093/nar/gkv1290. Epub 2015 Nov 28.
4
Database resources of the National Center for Biotechnology Information.美国国立生物技术信息中心的数据库资源。
Nucleic Acids Res. 2015 Jan;43(Database issue):D6-17. doi: 10.1093/nar/gku1130. Epub 2014 Nov 14.
5
Bioinformatics for cancer immunotherapy target discovery.用于癌症免疫治疗靶点发现的生物信息学
Cancer Immunol Immunother. 2014 Dec;63(12):1235-49. doi: 10.1007/s00262-014-1627-7. Epub 2014 Oct 26.
6
Combination of human leukocyte antigen and killer cell immunoglobulin-like receptor genetic background influences the onset age of hepatocellular carcinoma in male patients with hepatitis B virus infection.人类白细胞抗原与杀伤细胞免疫球蛋白样受体遗传背景的组合影响乙型肝炎病毒感染男性患者肝细胞癌的发病年龄。
Clin Dev Immunol. 2013;2013:874514. doi: 10.1155/2013/874514. Epub 2013 Nov 10.
7
Database resources of the National Center for Biotechnology Information.国家生物技术信息中心数据库资源。
Nucleic Acids Res. 2014 Jan;42(Database issue):D7-17. doi: 10.1093/nar/gkt1146. Epub 2013 Nov 19.
8
Database resources of the National Center for Biotechnology Information.国家生物技术信息中心数据库资源。
Nucleic Acids Res. 2013 Jan;41(Database issue):D8-D20. doi: 10.1093/nar/gks1189. Epub 2012 Nov 27.
9
Evaluation of human leukocyte antigen-A (HLA-A), other non-HLA markers on chromosome 6p21 and risk of nasopharyngeal carcinoma.人类白细胞抗原-A（HLA-A）、6p21 染色体上其他非 HLA 标志物评估与鼻咽癌风险的关系。
PLoS One. 2012;7(8):e42767. doi: 10.1371/journal.pone.0042767. Epub 2012 Aug 7.
10
Structural and functional studies of trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) protein molecule.转译 HLA-DQ2.3（DQA1*03:01/DQB1*02:01）蛋白分子的结构与功能研究。
J Biol Chem. 2012 Apr 20;287(17):13611-9. doi: 10.1074/jbc.M111.320374. Epub 2012 Feb 23.
本文引用的文献
1
IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex.IMGT/HLA和IMGT/MHC：用于主要组织相容性复合体研究的序列数据库。
Nucleic Acids Res. 2003 Jan 1;31(1):311-4. doi: 10.1093/nar/gkg070.
2
Cn3D: sequence and structure views for Entrez.Cn3D：Entrez的序列与结构视图。
Trends Biochem Sci. 2000 Jun;25(6):300-2. doi: 10.1016/s0968-0004(00)01561-9.
3
Cn3D: a new generation of three-dimensional molecular structure viewer.Cn3D：新一代三维分子结构查看器。
Trends Biochem Sci. 1997 Aug;22(8):314-6. doi: 10.1016/s0968-0004(97)01093-1.
4
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.空位BLAST和位置特异性迭代BLAST：新一代蛋白质数据库搜索程序。
Nucleic Acids Res. 1997 Sep 1;25(17):3389-402. doi: 10.1093/nar/25.17.3389.
5
Basic local alignment search tool.基本局部比对搜索工具
J Mol Biol. 1990 Oct 5;215(3):403-10. doi: 10.1016/S0022-2836(05)80360-2.
Zotero 插件