Dale P O, Tanbo T, Vaaler S, Abyholm T
University of Oslo, Norway.
Fertil Steril. 1992 Sep;58(3):487-91. doi: 10.1016/s0015-0282(16)55249-2.
To investigate the impact of body weight (BW) and insulin levels on gonadotropin and androgen levels in women with the polycystic ovarian syndrome (PCOS).
Comparative study of endocrinologic parameters in PCOS women.
University Hospital Reproductive Endocrinology Unit.
Thirty obese and 19 nonobese women with PCOS. Seven obese and 7 nonobese normal women.
Serum concentrations of insulin, testosterone, androstenedione, luteinizing hormone (LH), follicle-stimulating hormone. Serum LH response to gonadotropin-releasing hormone (GnRH) administration and assessment of insulin resistance by the continuous infusion of glucose with model assessment (CIGMA) test.
Fasting insulin levels correlated with body mass index (BMI). Basal LH levels correlated inversely with BMI. Nonobese women with PCOS had a higher LH response to GnRH than obese women with PCOS. Only obese women with PCOS showed insulin resistance and fasting hyperinsulinemia.
The data suggest that women with PCOS may be divided into two subgroups: those with obesity, insulin resistance, hyperinsulinemia, and normal/minimally elevated LH levels and those with normal BW, elevated LH levels, and normoinsulinemia.
探讨体重（BW）和胰岛素水平对多囊卵巢综合征（PCOS）女性促性腺激素和雄激素水平的影响。
PCOS女性内分泌参数的比较研究。
大学医院生殖内分泌科。
30名肥胖和19名非肥胖的PCOS女性。7名肥胖和7名非肥胖的正常女性。
血清胰岛素、睾酮、雄烯二酮、黄体生成素（LH）、卵泡刺激素的浓度。血清LH对促性腺激素释放激素（GnRH）给药的反应以及通过葡萄糖持续输注模型评估（CIGMA）试验评估胰岛素抵抗。
空腹胰岛素水平与体重指数（BMI）相关。基础LH水平与BMI呈负相关。非肥胖的PCOS女性对GnRH的LH反应高于肥胖的PCOS女性。只有肥胖的PCOS女性表现出胰岛素抵抗和空腹高胰岛素血症。
数据表明，PCOS女性可能分为两个亚组：肥胖、胰岛素抵抗、高胰岛素血症且LH水平正常/轻度升高的女性，以及体重正常、LH水平升高且胰岛素血症正常的女性。
