Levinson B, Wright P, Barklem S
S Afr Med J. 1985 Aug 31;68(5):302-7.
A double-blind, placebo-controlled clinical study of the efficacy and safety of buflomedil in the treatment of dementia was conducted in 55 patients. A statistically significant improvement was achieved for such characteristics as mood, self-care, alertness, emotional lability, indifference, hostility, and anxiety. Compared with placebo, buflomedil showed a clear superiority with regard to improvement in cognitive dysfunction and psychosomatic dysfunction, with a trend toward statistical significance in improvement in interpersonal relations. Secondary analysis of a subset of patients without evidence of earlier cerebrovascular accident showed similar clinical responses and statistical findings. Buflomedil was well tolerated.
对55例患者进行了一项关于丁咯地尔治疗痴呆疗效和安全性的双盲、安慰剂对照临床研究。在情绪、自我护理、警觉性、情绪不稳定、冷漠、敌意和焦虑等特征方面取得了具有统计学意义的改善。与安慰剂相比，丁咯地尔在改善认知功能障碍和心身功能障碍方面表现出明显优势，在改善人际关系方面有统计学意义的趋势。对一组无早期脑血管意外证据患者的二次分析显示了相似的临床反应和统计结果。丁咯地尔耐受性良好。
