Davis M E, Maxwell C V, Erf G F, Brown D C, Wistuba T J
Department of Animal Science, University of Arkansas, Fayetteville 72701, USA.
J Anim Sci. 2004 Jun;82(6):1882-91. doi: 10.2527/2004.8261882x.
Phosphorylated mannans derived from the yeast cell wall of Saccharomyces cerevisiae may beneficially modulate immune function in the weanling pig, possibly providing an alternative to the use of dietary growth-promoting antibiotics. Therefore, in this study, 32 pigs averaging 19 d of age and 5.7 +/- 0.2 kg initial BW were randomly assigned to 16 pens in an environmentally controlled nursery to determine the effects of dietary supplementation with phosphorylated mannans on growth and immune function. Average daily gain and G:F ratio increased (P < 0.05) when pigs were fed diets supplemented with mannans from d 0 to 14 after weaning and in the overall experiment. Percentage of neutrophils was lower (P < 0.08) and percentage of lymphocytes was higher (P < 0.05) in blood from pigs fed mannans than when pigs were fed the basal diet. Lamina propria macrophages isolated from pigs fed diets containing mannans phagocytosed a greater (P < 0.05) number of sheep red blood cells (2.63 +/- 0.11) than did lamina propria macrophages isolated from pigs fed the basal diet (2.31 +/- 0.11). On d 19 after weaning, pigs fed diets supplemented with mannans tended to have a greater (P < 0.10) percentage of CD14+ lamina propria leukocytes than did pigs fed the basal diet. On d 21 following weaning, the percentage of CD14+MHCII+ leukocytes isolated from lamina propria tissue tended (P < 0.10) to be lower when pigs were fed mannans than when pigs were fed the basal diet. Pigs fed diets containing mannans had a lower (P < 0.05) ratio of CD3+CD4+:CD3+CD8+ T lymphocytes isolated from jejunal lamina propria tissue only on d 21 after weaning compared with pigs fed the basal diet. Supplementation of mannans in the diets of weanling pigs improved gain and efficiency, and intermittently affected selected components of the young pigs' immune function both systemically and enterically.
源自酿酒酵母细胞壁的磷酸化甘露聚糖可能有益地调节断奶仔猪的免疫功能，这可能为使用促生长抗生素提供一种替代方法。因此，在本研究中，将32头平均19日龄、初始体重5.7±0.2 kg的仔猪随机分配到环境控制的保育舍中的16个围栏中，以确定日粮中添加磷酸化甘露聚糖对生长和免疫功能的影响。在断奶后第0天至14天以及整个实验期间，给仔猪饲喂添加了甘露聚糖的日粮时，平均日增重和料重比增加（P<0.05）。与饲喂基础日粮的仔猪相比，饲喂甘露聚糖的仔猪血液中的中性粒细胞百分比更低（P<0.08），淋巴细胞百分比更高（P<0.05）。从饲喂含甘露聚糖日粮的仔猪中分离出的固有层巨噬细胞吞噬绵羊红细胞的数量（2.63±0.11）比从饲喂基础日粮的仔猪中分离出的固有层巨噬细胞（2.31±0.11）更多（P<0.05）。断奶后第19天，饲喂添加甘露聚糖日粮的仔猪的固有层白细胞中CD14+的百分比往往高于饲喂基础日粮的仔猪（P<0.10）。断奶后第21天，与饲喂基础日粮的仔猪相比，饲喂甘露聚糖的仔猪从固有层组织中分离出的CD14+MHCII+白细胞百分比往往更低（P<0.10）。仅在断奶后第21天，与饲喂基础日粮的仔猪相比，饲喂含甘露聚糖日粮的仔猪从空肠固有层组织中分离出的CD3+CD4+:CD3+CD8+ T淋巴细胞比例更低（P<0.05）。在断奶仔猪日粮中添加甘露聚糖可提高生长性能和效率，并间歇性地全身性和肠道性影响仔猪免疫功能的某些选定成分。
