Vilozny Boaz, Amagata Taro, Mooberry Susan L, Crews Phillip
Department of Chemistry and Biochemistry and Institute for Marine Sciences, University of California, Santa Cruz, California 95064, USA.
J Nat Prod. 2004 Jun;67(6):1055-7. doi: 10.1021/np0340753.
Latrunculeic acid (3), a novel analogue of latrunculin B (2a), was isolated from the Red Sea sponge Negombata magnifica and characterized. Several known compounds were also isolated, including latrunculin B (2a), 15-methoxylatrunculin B (2b), 16-epi-latrunculin B (4), and latrunculin C (5). In contrast to the other members of the latrunculin family, the novel compound 3 is a polyketide devoid of the normal macrocyclic and thiazolidinone rings present in previously identified members of this family.
Latrunculeic acid（3）是一种新型的拉春库林B（2a）类似物，它从红海海绵Negombata magnifica中分离得到并进行了表征。还分离出了几种已知化合物，包括拉春库林B（2a）、15-甲氧基拉春库林B（2b）、16-表拉春库林B（4）和拉春库林C（5）。与拉春库林家族的其他成员不同，新型化合物3是一种聚酮化合物，没有该家族先前鉴定成员中存在的正常大环和噻唑烷酮环。
