Kato G J, Dang C V
Department of Pediatric, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
FASEB J. 1992 Sep;6(12):3065-72. doi: 10.1096/fasebj.6.12.1521738.
The c-Myc protein, the product of the c-myc proto-oncogene, is a nuclear phosphoprotein with DNA binding properties. Deregulated c-myc expression participates in the development of experimentally induced tumors, and its expression appears to be abnormal in many naturally occurring malignancies. Although the precise molecular mechanism of c-Myc activity in oncogenesis and in normal cell proliferation is unknown, recent advances have uncovered a series of molecular and cellular properties of c-Myc. These properties include nuclear localization, transcriptional activation, oligomerization nonspecific and specific DNA binding. Recently, the c-Myc protein was found to heterodimerize with Max, a protein that cooperates with c-Myc to bind specifically to a core DNA sequence, CAC(G/A)TG. These characteristics suggest that c-Myc participates in the regulation of gene transcription in normal and neoplastic cells.
c-Myc蛋白是原癌基因c-myc的产物，是一种具有DNA结合特性的核磷蛋白。c-myc表达失调参与实验诱导肿瘤的发生，在许多自然发生的恶性肿瘤中其表达似乎异常。尽管c-Myc在肿瘤发生和正常细胞增殖中的精确分子机制尚不清楚，但最近的进展揭示了c-Myc的一系列分子和细胞特性。这些特性包括核定位、转录激活、寡聚化、非特异性和特异性DNA结合。最近，发现c-Myc蛋白与Max异源二聚化，Max是一种与c-Myc协同作用以特异性结合核心DNA序列CAC(G/A)TG的蛋白。这些特征表明c-Myc参与正常和肿瘤细胞中基因转录的调控。
