Sakande Jean, Sawadogo Duni, Nacoulma Eric William Camille, Tiahou George, Gnagne Anne Chantal, Sess Essagne Daniel, Sangaré Amadou, Yapo Abbé Etienne
Laboratoire de biochimie médicale, CHU Yopougon, Abidjan, Cote D'Ivoire.
Sante. 2004 Jan-Mar;14(1):17-20.
Despite the high prevalence of neonatal anemia in Côte d'Ivoire, complete blood counts and iron studies have not been adequately explored. The authors studied complete blood counts (from peripheral blood mononuclear cells), hemoglobin electrophoresis results, and serum iron, ferritin and transferrin levels in 40 newborns and their mothers. The neonatal results (mean +/- SD) were: hemoglobin: 14.96 +/- 2.24 g/dl; serum iron: 16.88 +/- 7.29 micromol/l; total iron-binding capacity (TIBC): 39.88 +/- 14.85 micromol/l; transferrin: 2 +/- 0.65 g/l; ferritin: 116.20 +/- 105.25 microg/l; and hemoglobin electrophoresis: 22.5% of infants showed some hemoglobinopathy (FAC, FAS, FSA(2)). Maternal serum iron levels were positively correlated with the newborns' TIBC (r = 0.362, p<0.05), maternal ferritin with neonatal transferrin (r = 0.374, p<0.05), maternal transferrin coefficient of saturation (CS) with neonatal TIBC (r = 0.554, p<0.01). These results suggest a high prevalence of iron deficiency in mothers and a consequent potential risk of iron deficiency in their newborns in the absence of iron supplementation.
尽管科特迪瓦新生儿贫血的患病率很高，但全血细胞计数和铁代谢研究尚未得到充分探索。作者对40名新生儿及其母亲进行了全血细胞计数（来自外周血单核细胞）、血红蛋白电泳结果以及血清铁、铁蛋白和转铁蛋白水平的研究。新生儿的结果（均值±标准差）为：血红蛋白：14.96±2.24 g/dl；血清铁：16.88±7.29 μmol/l；总铁结合力（TIBC）：39.88±14.85 μmol/l；转铁蛋白：2±0.65 g/l；铁蛋白：116.20±105.25 μg/l；血红蛋白电泳：22.5%的婴儿显示出一些血红蛋白病（FAC、FAS、FSA(2)）。母亲血清铁水平与新生儿的TIBC呈正相关（r = 0.362，p<0.05），母亲铁蛋白与新生儿转铁蛋白呈正相关（r = 0.374，p<0.05），母亲转铁蛋白饱和度系数（CS）与新生儿TIBC呈正相关（r = 0.554，p<0.01）。这些结果表明母亲缺铁的患病率很高，在未补充铁的情况下，其新生儿有缺铁的潜在风险。
