Chihara E, Chihara K
Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
Graefes Arch Clin Exp Ophthalmol. 1992;230(5):416-20. doi: 10.1007/BF00175925.
The appearance of the retinal nerve fiber layer was studied in one eye of 203 normal Asians (59 with high myopia greater than or equal to -5 D, and 144 with emmetropia or hyperopia). "Cleavage" of the retinal nerve fiber layer was observed in 3 of these 59 highly myopic eyes, but there was no significant damage to either the retinal pigment epithelium or the choroid. In contrast, no cleavage was observed in the other 144 emmetropic or hyperopic eyes. High myopia (P = 0.0237, Fisher's exact test) was a significant risk factor for "cleavage" development in the retinal nerve fiber layer. The occurrence of a defect (nerve fiber loss) in the retinal nerve fiber layer in severe myopia (5/59, 8%) was also greater than that in either emmetropia or hyperopia (2/144, 1%; P = 0.0229). These results indicate that subtle changes can occur in the appearance of the retinal nerve fiber layer of the eye in some patients with asymptomatic myopia.
对203名正常亚洲人的一只眼睛的视网膜神经纤维层外观进行了研究（59名高度近视患者，近视度数大于或等于-5 D，144名正视或远视患者）。在这59只高度近视眼中，有3只观察到视网膜神经纤维层“劈裂”，但视网膜色素上皮或脉络膜均无明显损伤。相比之下，在其他144只正视或远视眼中未观察到劈裂。高度近视（P = 0.0237，Fisher精确检验）是视网膜神经纤维层发生“劈裂”的一个显著危险因素。严重近视患者视网膜神经纤维层出现缺损（神经纤维丢失）的发生率（5/59，8%）也高于正视或远视患者（2/144，1%；P = 0.0229）。这些结果表明，一些无症状近视患者的眼部视网膜神经纤维层外观可能会发生细微变化。
