O'Reilly K M A, Boscia J A, Kaplan K L, Sime P J
Dept of Medicine, Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA.
Eur Respir J. 2004 Jun;23(6):954-6. doi: 10.1183/09031936.04.00102404.
A case of pulmonary hyalinising granuloma (PHG) complicated by deep venous thrombosis (DVT) is presented. The DVT was associated with the presence of a lupus anticoagulant. In the past PHG has been linked to various auto-antibodies, but to the best of the authors' knowledge, this is the first case reporting PHG in association with a lupus anticoagulant and clinically significant venous thrombosis. Historically, PHG has been regarded as poorly corticosteroid responsive. However, the patient in this case study responded dramatically to prednisone. This case study suggests that in selected patients with pulmonary hyalinising granuloma experiencing disabling symptoms and worsening pulmonary function, a trial of corticosteroids may be warranted.
本文报告了一例肺透明变性肉芽肿（PHG）并发深静脉血栓形成（DVT）的病例。该DVT与狼疮抗凝物的存在有关。过去，PHG与多种自身抗体有关，但据作者所知，这是首例报告PHG与狼疮抗凝物及具有临床意义的静脉血栓形成相关的病例。从历史上看，PHG被认为对皮质类固醇反应不佳。然而，本病例研究中的患者对泼尼松反应显著。该病例研究表明，对于某些出现致残症状且肺功能恶化的肺透明变性肉芽肿患者，可能有必要试用皮质类固醇。
