深静脉血栓形成与狼疮抗凝物。一项病例对照研究。
Deep venous thrombosis and lupus anticoagulant. A case-control study.
作者信息
Simioni P, Prandoni P, Zanon E, Saracino M A, Scudeller A, Villalta S, Scarano L, Girolami B, Benedetti L, Girolami A
机构信息
Institute of Medical Semeiotics, University Hospital of Padua, Italy.
出版信息
Thromb Haemost. 1996 Aug;76(2):187-9.
BACKGROUND
A definite evidence in favour of an association of deep-vein thrombosis (DVT) with lupus anticoagulant (LA) in patients free from systemic lupus erythematosus is still lacking.
METHODS
In a case-control study, LA was determined in 176 consecutive outpatients who underwent phlebography because of the first episode of clinically suspected DVT of lower limbs. The association between DVT and LA was described using odds ratios (OR).
RESULTS
Contrast venography confirmed the clinical suspicion in 59 patients (33.5%). LA was detected in 5 of the 59 patients with DVT (8.5%), and in none of the 117 subjects with normal venogram (P = 0.007). The OR for having an acute DVT in patients with LA was 10.7 (95% CI: 1.2-94.2).
CONCLUSIONS
LA is significantly associated with DVT in symptomatic patients. Further studies are needed to establish the clinical implications of this association.
背景
在无系统性红斑狼疮的患者中，仍缺乏深静脉血栓形成（DVT）与狼疮抗凝物（LA）相关联的确切证据。
方法
在一项病例对照研究中，对176例因首次出现临床疑似下肢DVT而接受静脉造影的连续门诊患者进行了LA检测。使用比值比（OR）描述DVT与LA之间的关联。
结果
静脉造影证实59例患者（33.5%）临床怀疑成立。59例DVT患者中有5例检测到LA（8.5%），117例静脉造影正常的受试者中均未检测到LA（P = 0.007）。LA患者发生急性DVT的OR为10.7（95%CI：1.2 - 94.2）。
结论
在有症状的患者中，LA与DVT显著相关。需要进一步研究以确定这种关联的临床意义。
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