Sweet M B, Jakim I, Coelho A, Becker P J, Thonar E J
Bone and Joint Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Int J Sports Med. 1992 May;13(4):348-50. doi: 10.1055/s-2007-1021279.
The effect of strenuous joint loading on the metabolism of articular cartilage in man is not known. The development of a non-invasive immunoassay for the assessment of the catabolism of cartilage aggrecan has enabled us to quantify keratan sulfate (KS), a component of aggrecan, in the serum of fifteen male marathon runners. Serum KS was measured by an ELISA before and immediately after a marathon (42 km), as well as 48 hours after the completion of the race. The mean level at rest was similar to those previously reported for another population of age-matched males. There was no statistically significant difference in the serum level of KS at the three different readings. Further, there was no correlation between age, height, weight and performance time, and the serum level of KS at any of the three different times. We conclude that marathon running by carefully trained runners causes neither a transient nor a sustained increase in proteoglycan catabolism in articular cartilage.
剧烈的关节负荷对人体关节软骨代谢的影响尚不清楚。一种用于评估软骨聚集蛋白聚糖分解代谢的非侵入性免疫测定方法的开发，使我们能够对15名男性马拉松运动员血清中的硫酸角质素（KS）进行定量，硫酸角质素是聚集蛋白聚糖的一种成分。在马拉松比赛（42公里）前、比赛结束后立即以及比赛结束48小时后，通过酶联免疫吸附测定法（ELISA）测量血清KS。静息时的平均水平与先前报道的另一组年龄匹配男性的水平相似。在三个不同时间点的血清KS水平没有统计学上的显著差异。此外，在三个不同时间点的任何一个时间，年龄、身高、体重和比赛用时与血清KS水平之间均无相关性。我们得出结论，经过精心训练的跑步者进行马拉松跑步，既不会导致关节软骨中蛋白聚糖分解代谢的短暂增加，也不会导致其持续增加。
