Frey S, Kostopoulos P, Petrides M
Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, H3A 2B4, Canada.
Eur J Neurosci. 2000 Oct;12(10):3709-12. doi: 10.1046/j.1460-9568.2000.00227.x.
Although little is known about the contribution of the orbitofrontal cortex to the processing of new information in man, lesion studies in monkeys have suggested that it plays a critical role. The present study investigated changes in cerebral blood flow with positron emission tomography in normal human subjects during exposure to unpleasant auditory stimuli. The results indicated that the caudal orbitofrontal cortex, area 13, which is powerfully linked to the medial temporal limbic region and is involved in the regulation of autonomic responses, is a key part of the frontal cortex responding in the face of unpleasant incoming information.
虽然对于眶额皮质在人类处理新信息过程中的作用了解甚少，但对猴子的损伤研究表明它起着关键作用。本研究利用正电子发射断层扫描技术，调查了正常人类受试者在暴露于不愉快听觉刺激期间脑血流量的变化。结果表明，尾侧眶额皮质（13区）与内侧颞叶边缘区域紧密相连，并参与自主反应的调节，是额叶皮质在面对不愉快传入信息时做出反应的关键部分。
