Haupt Susan, Haupt Ygal
Department of Pharmaceutics, School of Pharmacy, The Hebrew University, Jerusalem 91120, Israel.
Semin Cancer Biol. 2004 Aug;14(4):244-52. doi: 10.1016/j.semcancer.2004.04.003.
The tumor suppressor p53 is a linchpin in the regulation of appropriate cellular responses to various stress conditions. Inactivation of the functions of this critical participant can have diabolical consequences, in particular the development of malignant diseases. Elicitation of appropriate p53 functions is an attractive strategy for combating cancer. Triggering p53 responses, reconstituting p53 activities through gene therapy, coercing mutant p53 to perform normal functions, manipulating p53 regulators, and activating p53 effectors are all approaches that are currently being developed. Here, we will overview 'p53-based' strategies for fighting cancer, both those under clinical trial and recent innovative concepts.
肿瘤抑制因子p53是调控细胞对各种应激条件做出适当反应的关键因素。这个关键参与者功能的失活可能会产生极其严重的后果，尤其是引发恶性疾病。激发p53的适当功能是对抗癌症的一个有吸引力的策略。触发p53反应、通过基因疗法重建p53活性、迫使突变型p53发挥正常功能、操纵p53调节因子以及激活p53效应器都是目前正在研发的方法。在此，我们将概述用于对抗癌症的“基于p53”的策略，包括那些正在进行临床试验的策略以及近期的创新理念。
