Liu Xinkui, Wu Jiarui, Zhang Dan, Wang Kaihuan, Duan Xiaojiao, Zhang Xiaomeng
Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
Evid Based Complement Alternat Med. 2018 Feb 12;2018:6517034. doi: 10.1155/2018/6517034. eCollection 2018.
As one of the most frequently diagnosed cancer diseases globally, colorectal cancer (CRC) remains an important cause of cancer-related death. Although the traditional Chinese herb Willd. (HDW) has been proven to be effective for treating CRC in clinical practice, its definite mechanisms have not been completely deciphered.
The aim of our research is to systematically explore the multiple mechanisms of HDW on CRC.
This study adopted the network pharmacology approach, which was mainly composed of active component gathering, target prediction, CRC gene collection, network analysis, and gene enrichment analysis.
The network analysis showed that 10 targets might be the therapeutic targets of HDW on CRC, namely, HRAS, PIK3CA, KRAS, TP53, APC, BRAF, GSK3B, CDK2, AKT1, and RAF1. The gene enrichment analysis implied that HDW probably benefits patients with CRC by modulating pathways related to cancers, infectious diseases, endocrine system, immune system, nervous system, signal transduction, cellular community, and cell motility.
This study partially verified and predicted the pharmacological and molecular mechanism of HDW against CRC from a holistic perspective, which will also lay a foundation for the further experimental research and clinical rational application of HDW.
作为全球最常被诊断出的癌症疾病之一，结直肠癌（CRC）仍是癌症相关死亡的一个重要原因。尽管传统中药白花蛇舌草（HDW）在临床实践中已被证明对治疗结直肠癌有效，但其确切机制尚未完全阐明。
我们研究的目的是系统地探索白花蛇舌草对结直肠癌的多种作用机制。
本研究采用网络药理学方法，主要包括活性成分收集、靶点预测、结直肠癌基因收集、网络分析和基因富集分析。
网络分析表明，10个靶点可能是白花蛇舌草治疗结直肠癌的靶点，即HRAS、PIK3CA、KRAS、TP53、APC、BRAF、GSK3B、CDK2、AKT1和RAF1。基因富集分析表明，白花蛇舌草可能通过调节与癌症、传染病、内分泌系统、免疫系统、神经系统、信号转导、细胞群落和细胞运动相关的途径使结直肠癌患者受益。
本研究从整体角度部分验证并预测了白花蛇舌草抗结直肠癌的药理和分子机制，这也将为白花蛇舌草进一步的实验研究和临床合理应用奠定基础。
