Ho Hoi-Por, Westberg Lars, Annerbrink Kristina, Olsson Marie, Melke Jonas, Nilsson Staffan, Baghaei Fariba, Rosmond Roland, Holm Göran, Björntorp Per, Andersch Sven, Allgulander Christer, Eriksson Elias
Department of Pharmacology, Göteborg University, P.O.B. 431, SE 405 30 Göteborg, Sweden.
Psychoneuroendocrinology. 2004 Oct;29(9):1138-41. doi: 10.1016/j.psyneuen.2004.01.005.
Although genetic factors are known to be important risk factors for panic disorder there is as yet no conclusive data regarding specific gene variants. Prompted by evidence supporting progesterone to influence the pathophysiology of panic disorder, polymorphisms in the progesterone receptor gene, a single nucleotide polymorphism (G331A) and an insertion/deletion polymorphism (PROGINS) were investigated in 72 patients with panic disorder and 452 controls. The frequency of the A-allele of the G331A polymorphism was higher in panic disorder patients than in controls (p = 0.01). When male and female patients were analyzed separately, the association was observed in female patients only (p = 0.0009), with an odds ratio of 3.5. No differences between groups were observed for the PROGINS polymorphism. In conclusion, these data suggest that the G331A polymorphism in the progesterone receptor gene may influence the risk for panic disorder in women.
尽管已知遗传因素是惊恐障碍的重要风险因素，但关于特定基因变异尚无确凿数据。鉴于有证据支持孕酮会影响惊恐障碍的病理生理学，我们对72例惊恐障碍患者和452名对照者的孕酮受体基因多态性进行了研究，包括一个单核苷酸多态性（G331A）和一个插入/缺失多态性（PROGINS）。惊恐障碍患者中G331A多态性的A等位基因频率高于对照组（p = 0.01）。当分别分析男性和女性患者时，仅在女性患者中观察到这种关联（p = 0.0009），优势比为3.5。PROGINS多态性在两组之间未观察到差异。总之，这些数据表明孕酮受体基因中的G331A多态性可能会影响女性患惊恐障碍的风险。
