Annerbrink Kristina, Westberg Lars, Olsson Marie, Andersch Sven, Sjödin Ingemar, Holm Göran, Allgulander Christer, Eriksson Elias
Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.
Psychiatr Genet. 2011 Apr;21(2):85-9. doi: 10.1097/YPG.0b013e328341a3db.
Orexin A and B are neuropeptides influencing, for example, arousal and respiration. Although panic disorder is characterized by both enhanced proneness for arousal and by respiratory abnormalities, the possible influence of orexin-related genes on the risk of developing this disorder has not been studied until now.
We have analyzed the Ile408Val polymorphism in the hypocretin receptor 1 (HCRTR1) gene and the Val308Iso (G1246A) polymorphism in the hypocretin receptor 2 (HCRTR2) gene in a sample of 215 panic disorder patients and 454 controls.
Although the polymorphism in the HCRTR1 did not differ between groups, the Iso allele of the HCRTR2 polymorphism was significantly more frequent in patients than in controls. After the population was divided according to sex, the association between the Iso allele of the Val308Iso polymorphism and panic disorder was observed only in female patients.
Our results suggest that the HCRTR2 polymorphism may be of importance for the pathophysiology of panic disorder. The results should be regarded as preliminary until replicated in an independent sample. This indicates that further research on the possible role of orexin in panic disorder may prove rewarding.
食欲素A和B是影响例如觉醒和呼吸的神经肽。尽管惊恐障碍的特征是觉醒倾向增强和呼吸异常，但食欲素相关基因对患该疾病风险的可能影响至今尚未得到研究。
我们在215例惊恐障碍患者和454例对照样本中分析了下丘脑分泌素受体1（HCRTR1）基因的Ile408Val多态性和下丘脑分泌素受体2（HCRTR2）基因的Val308Iso（G1246A）多态性。
尽管HCRTR1的多态性在两组间无差异，但HCRTR2多态性的Iso等位基因在患者中显著比对照中更常见。按性别对人群进行划分后，仅在女性患者中观察到Val308Iso多态性的Iso等位基因与惊恐障碍之间的关联。
我们的结果表明，HCRTR2多态性可能对惊恐障碍的病理生理学具有重要意义。在独立样本中重复验证之前，这些结果应被视为初步的。这表明对食欲素在惊恐障碍中可能作用的进一步研究可能会有收获。
