季节性变应性结膜炎患者泪液中嗜酸性粒细胞趋化因子-1（CCL11）上调。

Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis.

作者信息

Eperon Simone, Sauty Alain, Lanz René, Leimgruber Annette, Lurati Floriana, Guex-Crosier Yan

机构信息

Ocular Immunology, Jules Gonin Eye Hospital, Av. De France 15, 1000, Lausanne 7, Switzerland.

出版信息

Graefes Arch Clin Exp Ophthalmol. 2004 Nov;242(11):966-70. doi: 10.1007/s00417-004-0943-6. Epub 2004 Jun 25.

DOI:10.1007/s00417-004-0943-6

PMID:15221302

Abstract

PURPOSE

To compare in-season eotaxin-1 levels in tears of patients suffering from seasonal allergic conjunctivitis (SAC) with (1) tears of normal subjects and (2) tears of SAC patients out of season.

METHODS

Tears of 11 SAC patients and six control volunteers were collected during the pollen season. Tears of five SAC patients showing a strong sensitivity to grass pollen (skin-prick tests and specific serum IgE) were collected both in season and out of season. ELISA measured eotaxin-1 level.

RESULTS

Eotaxin-1 concentration in tears of SAC patients [2,100+/-503 (SEM) pg/ml] and normal subjects (1,193+/-176 pg/ml) were significantly different (P=0.0049). Regarding allergic patients, the clinical score (sum of five allergic criteria) was significantly different in season and out of season (P=0.0043) as was also the case with eotaxin-1 concentration (P=0.024).

CONCLUSIONS

The eotaxin-1 concentration in tears of patients showing hay fever could confirm a diagnosis of seasonal ocular allergy.

摘要

目的

比较季节性变应性结膜炎（SAC）患者泪液中嗜酸性粒细胞趋化因子-1水平与（1）正常受试者泪液以及（2）非花粉季节SAC患者泪液中的嗜酸性粒细胞趋化因子-1水平。

方法

在花粉季节收集11例SAC患者和6名对照志愿者的泪液。收集5例对草花粉高度敏感（皮肤点刺试验和特异性血清IgE）的SAC患者在花粉季节和非花粉季节的泪液。采用酶联免疫吸附测定法检测嗜酸性粒细胞趋化因子-1水平。

结果

SAC患者泪液中嗜酸性粒细胞趋化因子-1浓度[2,100±503（SEM）pg/ml]与正常受试者（1,193±176 pg/ml）有显著差异（P = 0.0049）。对于变应性患者，临床评分（五项变应性标准之和）在花粉季节和非花粉季节有显著差异（P = 0.0043），嗜酸性粒细胞趋化因子-1浓度亦是如此（P = 0.024）。