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植物内体系统——其结构以及在信号转导和植物发育中的作用。

The plant endosomal system--its structure and role in signal transduction and plant development.

作者信息

Geldner Niko

机构信息

ZMBP, Entwicklungsgenetik, Universität Tübingen, Auf der Morgenstelle 3, 72076, Germany.

出版信息

Planta. 2004 Aug;219(4):547-60. doi: 10.1007/s00425-004-1302-x. Epub 2004 Jun 22.

Abstract

Endosomes are highly dynamic membrane systems that receive endocytosed plasma membrane proteins and sort them for either degradation or recycling back to the cell surface. In addition, they receive newly synthesised proteins destined for vacuolar/lysosomal compartments. Sorting in the endosomes is necessary for the establishment and maintenance of cell polarity and it is needed to control levels and function of receptors and transporters at the cellular surface. Both processes are crucial for correct cell behaviour during tissue and organ development and for intercellular communication in general. It has therefore become an imperative to investigate structure and function of the endosomal system if we want to obtain a deeper mechanistic understanding of signal transduction and development. This review will compare our current understanding of endosomal trafficking in animals and yeast with what is known in plants, and will highlight some important breakthroughs in our understanding of the role of endosomes in signal transduction and multicellular development in Drosophila, as well as in Arabidopsis.

摘要

内涵体是高度动态的膜系统,它接收经胞吞作用内化的质膜蛋白,并对其进行分类以便降解或循环回到细胞表面。此外,它们还接收新合成的、 destined for vacuolar/lysosomal compartments(此处“destined for vacuolar/lysosomal compartments”表述有误,推测可能是“ destined for vacuolar/lysosomal compartments”,可译为“运往液泡/溶酶体区室”)的蛋白质。内涵体中的分类对于细胞极性的建立和维持是必要的,并且对于控制细胞表面受体和转运蛋白的水平及功能也是必需的。这两个过程对于组织和器官发育过程中的正确细胞行为以及一般的细胞间通讯都至关重要。因此,如果我们想要更深入地从机制上理解信号转导和发育,研究内涵体系统的结构和功能就变得势在必行。本综述将比较我们目前对动物和酵母中内涵体运输的理解与植物中的已知情况,并将突出我们在理解内涵体在果蝇以及拟南芥的信号转导和多细胞发育中的作用方面的一些重要突破。

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