Cirak V Y, Güleğen E, Bauer C
Department of Parasitology, Faculty of Veterinary Medicine, Uludağ University, 16059 Görükle-Bursa, Turkey.
Parasitol Res. 2004 Aug;93(5):392-5. doi: 10.1007/s00436-004-1143-3. Epub 2004 Jun 18.
A cross-sectional survey was performed on ten stud farms in western Anatolia, Turkey, in order to provide the first information on the problem of anthelmintic resistance in equine strongyles in this country. Benzimidazole (BZ) resistant cyathostomin populations were detected on seven farms if pre- and post-treatment egg counts are compared in treated animals and the resistance is defined as a mean faecal egg count reduction (FECR) of <95% with a lower 95% confidence limit of <90%. Egg hatch tests using an ED(50) of 0.1 microg/ml thiabendazole as the cut-off value confirmed BZ resistance on four of the seven farms. The probable reasons for the occurrence of BZ resistance are discussed. Resistance to pyrantel embonate or macrocyclic lactones, evaluated on five and six farms, respectively, was not detected using the FECR test.
为了获取土耳其安纳托利亚西部十个种马场马圆线虫驱虫抗性问题的首批信息,开展了一项横断面调查。如果比较治疗动物治疗前后的虫卵计数,且将抗性定义为粪便虫卵计数减少(FECR)平均值<95%,95%置信下限<90%,则在七个马场检测到了对苯并咪唑(BZ)耐药的杯状类圆线虫种群。以0.1微克/毫升噻苯达唑的半数有效剂量(ED50)作为临界值进行的虫卵孵化试验,证实了七个马场中有四个存在BZ抗性。文中讨论了出现BZ抗性的可能原因。分别在五个和六个马场评估了对吡喹酮或大环内酯类的抗性,通过FECR试验未检测到抗性。