结直肠癌患者血清钙水平与CA 19-9水平的关系。
Relationship between serum calcium and CA 19-9 levels in colorectal cancer.
作者信息
Fuszek Peter, Lakatos Peter, Tabak Adam, Papp Janos, Nagy Zsolt, Takacs Istvan, Horvath Henrik Csaba, Lakatos Peter Laszlo, Speer Gabor
机构信息
1st Department of Medicine, Faculty of Medicine, Semmelweis University, 1083 Budapest, Koronyi S. u. 2/a, Hungary.
出版信息
World J Gastroenterol. 2004 Jul 1;10(13):1890-2. doi: 10.3748/wjg.v10.i13.1890.
AIM
To examine the calcium metabolism of colorectal cancer (CRC) in patients with colorectal cancer and control patients.
METHODS
Seventy newly diagnosed CRC patients were included. The healthy control group was age and gender matched (n=32). Particular attention was devoted to the relationship between serum calcium of patients, and levels of AFP, CEA, carbohydrate antigen 19-9 (CA 19-9) (that could be considered as prognostic factors). Furthermore, the Ca-sensing receptor (CaSR) gene A986S polymorphism was investigated in these patients, as well as the relationship between different CaSR genotypes and the data stated above.
RESULTS
A lower level of ionized calcium (also corrected for albumin) was found in the serum of CRC patients with normal 25(OH) vitamin D levels. The ionized calcium concentration was inversely correlated with the serum level of CA 19-9. There was no difference in the distribution of CaSR genotypes, between CRC patients and general population. The genotypes did not correlate with other data examined.
CONCLUSION
Based on these results, lower levels of serum calcium might be a pathogenic and prognostic factor in colorectal cancer.
目的
研究结直肠癌患者及对照患者的结直肠癌钙代谢情况。
方法
纳入70例新诊断的结直肠癌患者。健康对照组在年龄和性别上进行匹配（n = 32）。特别关注患者血清钙与甲胎蛋白（AFP）、癌胚抗原（CEA）、糖类抗原19 - 9（CA 19 - 9）水平之间的关系（这些可被视为预后因素）。此外，还研究了这些患者中钙敏感受体（CaSR）基因A986S多态性，以及不同CaSR基因型与上述数据之间的关系。
结果
在25（OH）维生素D水平正常的结直肠癌患者血清中发现离子钙水平较低（也校正了白蛋白）。离子钙浓度与CA 19 - 9血清水平呈负相关。结直肠癌患者与普通人群之间CaSR基因型分布无差异。这些基因型与所检测的其他数据无关。
结论
基于这些结果，血清钙水平降低可能是结直肠癌的一个致病和预后因素。
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