慢性肝病问卷：在泰国人的翻译与验证
Chronic liver disease questionnaire: translation and validation in Thais.
作者信息
Sobhonslidsuk Abhasnee, Silpakit Chatchawan, Kongsakon Ronnachai, Satitpornkul Patchareeya, Sripetch Chaleaw
机构信息
Department of Medicine, Ramathibodi Hospital, 270 Praram 6 Road, Bangkok 10400, Thailand.
出版信息
World J Gastroenterol. 2004 Jul 1;10(13):1954-7. doi: 10.3748/wjg.v10.i13.1954.
AIM
Quality of life (QOL) is a concept that incorporates many aspects of life beyond "health". The chronic liver disease questionnaire (CLDQ) was developed to evaluate the impact of chronic liver diseases (CLD) on QOL. The objectives of this study were to translate and validate a liver specific questionnaire, the CLDQ.
METHODS
The CLDQ was formally translated from the original version to Thai language with permission. The translation process included forward translation, back translation, cross-cultural adaptation and a pretest. Reliability and validity of the translated version was examined in CLD patients. Enrolled subjects included CLD and normal subjects with age- and sex-matched. Collected data were demography, physical findings and biochemical tests. All subjects were asked to complete the translated versions of CLDQ and SF-36, which was previously validated. Cronbach's alpha and test-retest were performed for reliability analysis. One-way Anova or non-parametric method was used to determine discriminant validity. Spearman's rank correlation was used to assess convergent validity. P -value <0.05 was considered statistically significant.
RESULTS
A total of 200 subjects were recruited into the study, with 150 CLD and 50 normal subjects. Mean ages (SD) were 47.3(11.7) and 49.1(8.5) years, respectively. The number of chronic hepatitis: cirrhosis was 76:74, and the ratio of cirrhotic patients classified as Child A:B:C was 37(50%): 26(35%): 11(15%). Cronbach's alpha of the overall CLDQ scores was 0.96 and of all domains were higher than 0.93. Item-total correlation was >0.45. Test-retest reliability done at 1 to 4 wk apart was 0.88 for the average CLDQ score and from 0.68 to 0.90 for domain scores. The CLDQ was found to have discriminant validity. The highest scores of CLDQ domains were in the normal group, scores were lower in the compensated group and lowest in the decompensated group. The significant correlation between domains of the CLDQ and SF-36 was found. The average CLDQ score was strongly correlated with the general health domain of SF-36. (P=0.69: P=0.01).
CONCLUSION
The translated CLDQ is valid and applicable in Thais with CLD. CLDQ reveals that QOL in these patients is lower than that in normal population. QOL is more impaired in advanced stage of CLD.
目的
生活质量（QOL）是一个包含“健康”以外生活诸多方面的概念。慢性肝病问卷（CLDQ）旨在评估慢性肝病（CLD）对生活质量的影响。本研究的目的是翻译并验证一份肝脏特异性问卷——CLDQ。
方法
经许可将CLDQ从原始版本正式翻译成泰语。翻译过程包括正向翻译、反向翻译、跨文化调适和预测试。在CLD患者中检验翻译后版本的信度和效度。纳入的受试者包括CLD患者和年龄及性别匹配的正常受试者。收集的数据包括人口统计学信息、体格检查结果和生化检查。所有受试者均被要求完成翻译后的CLDQ和之前已验证的SF - 36。采用Cronbach's α系数和重测法进行信度分析。采用单因素方差分析或非参数方法确定区分效度。采用Spearman等级相关评估聚合效度。P值<0.05被认为具有统计学意义。
结果
本研究共招募了200名受试者，其中150名CLD患者和50名正常受试者。平均年龄（标准差）分别为47.3（11.7）岁和49.1（8.5）岁。慢性肝炎与肝硬化的例数为76:74，肝硬化患者按Child A:B:C分类的比例为37（50%）:26（35%）:11（15%）。CLDQ总分的Cronbach's α系数为0.96，所有维度均高于0.93。项目与总分的相关性>0.45。间隔1至4周进行的重测信度显示，CLDQ平均得分的重测信度为0.88，各维度得分的重测信度为0.68至0.90。发现CLDQ具有区分效度。CLDQ各维度得分最高的是正常组，代偿组得分较低，失代偿组得分最低。发现CLDQ各维度与SF - 36之间存在显著相关性。CLDQ平均得分与SF - 36的总体健康维度密切相关。（P = 0.69，P = 0.01）。
结论
翻译后的CLDQ在泰国CLD患者中有效且适用。CLDQ显示这些患者的生活质量低于正常人群。CLD晚期患者的生活质量受损更严重。
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