Ray Irene, Dutta Deep, Basu Pallavi, De Binay K
Department of Medicine, Medical College and Hospitals Calcutta, 88, College Street, Kolkata 700073, India.
Indian J Gastroenterol. 2010 Sep;29(5):187-95. doi: 10.1007/s12664-010-0036-x. Epub 2010 Aug 26.
The aim of this study was to translate and validate chronic liver disease questionnaire (CLDQ) into Bengali using a standard protocol and use it to assess the impact of socioeconomic factors, etiology, disease severity and complications on the quality of life of patients.
Formal translation of CLDQ to Bengali was done. Cronbach's alpha and test-retest was performed for reliability analysis. Patients with clinically stable chronic liver disease (CLD) without significant associated co-morbid states were administered Bengali CLDQ in the Liver Clinic. The clinical, biochemical and disease parameters were recorded for analysis.
Bengali CLDQ was administered to 100 patients with CLD. Cronbach's alpha of overall scores was 0.90 and test-retest correlation coefficient of average CLDQ was 0.86 (P<0.001). Patients with history of decompensation (96.51 vs. 109.61; P=0.039) and Child's C status (92.24 vs. 105.71; P=0.028) had significantly lower CLDQ scores. CLDQ scores showed a moderate inverse correlation with Child's status (r= -0.35) and a poor correlation with MELD score (r= -0.09).
Bengali translation of CLDQ was found to be reliable. History of decompensation, Child's C status was associated with worse CLDQ scores. Child's status may have some role in predicting quality of life of patients with CLD. MELD score had poor predictability of quality of life.
本研究旨在使用标准方案将慢性肝病问卷（CLDQ）翻译成孟加拉语并进行验证，并使用该问卷评估社会经济因素、病因、疾病严重程度和并发症对患者生活质量的影响。
对CLDQ进行正式的孟加拉语翻译。进行Cronbach's α系数分析和重测以进行可靠性分析。在肝病门诊对临床稳定、无显著合并症的慢性肝病（CLD）患者发放孟加拉语版CLDQ。记录临床、生化和疾病参数以进行分析。
对100例CLD患者发放了孟加拉语版CLDQ。总分的Cronbach's α系数为0.90，CLDQ平均分的重测相关系数为0.86（P<0.001）。有失代偿史的患者（96.51对109.61；P=0.039）和Child's C级状态的患者（92.24对105.71；P=0.028）的CLDQ得分显著较低。CLDQ得分与Child's分级呈中度负相关（r = -0.35），与终末期肝病模型（MELD）评分相关性较差（r = -0.09）。
CLDQ的孟加拉语翻译可靠。失代偿史、Child's C级状态与较差的CLDQ得分相关。Child's分级可能在预测CLD患者生活质量方面有一定作用。MELD评分对生活质量的预测性较差。
