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北欧国家成年人群血红蛋白、基本血细胞计数及红细胞指数参考区间的多中心研究。

A multicentre study of reference intervals for haemoglobin, basic blood cell counts and erythrocyte indices in the adult population of the Nordic countries.

作者信息

Nordin G, Mårtensson A, Swolin B, Sandberg S, Christensen N J, Thorsteinsson V, Franzson L, Kairisto V, Savolainen E-R

机构信息

EQUALIS AB, Box 977, SE-751 99 Uppsala, Sweden.

出版信息

Scand J Clin Lab Invest. 2004;64(4):385-98. doi: 10.1080/00365510410002797.

Abstract

Eight haematological quantities were measured in EDTA anticoagulated venous blood specimens collected from 1826 healthy male and female individuals between 18 and 90 years of age in the Nordic countries (Denmark, Finland, Iceland, Norway and Sweden). The samples, collected between November 1999 and November 2001 as part of the Nordic Reference Interval Project (NORIP), were analysed on 12 different types of modern automated haematology instruments currently in use among the 60 laboratories participating in the study. Non-parametric reference intervals (between 2.5 and 97.5 percentiles) have been calculated for B-Haemoglobin (females 117-153 g/L, males 134-170 g/L), B-Erythrocytes (females 3.94-5.16 x 10(12)/L, males 4.25-5.71 x 10(12)/L), B-EVF (females 0.348-0.459, males 0.395-0.500), B-MCV (82-98 fL), Erc-MCH (27.1-33.3 pg), Erc-MCHC (317-357 g/L), B-Trc (females 165-387 x 10(9)/L, males 145 x 348 x 10(9)/L) and B-Lkc (3.5-8.8 x 10(9)/L). Partitioning of data according to age and gender was done according to a standardized procedure. For most variables the calculated reference intervals corresponded well with older and less well-defined reference intervals. The mean concentration of B-Haemoglobin increased by 0.08 g/L per year of age in women, and decreased by 0.1 g/L per year of age in men. B-Haemoglobin increased with body mass index in both men and women. Smoking increased the mean of B-Lkc by 1.1 x 10(9)/L and regular use of alcohol increased the mean of B-MCV by 0.8 fL. The influence of these factors was small overall and did not promote specific reference intervals.

摘要

在北欧国家(丹麦、芬兰、冰岛、挪威和瑞典),从1826名年龄在18至90岁之间的健康男性和女性身上采集了乙二胺四乙酸(EDTA)抗凝的静脉血样本,并测量了八项血液学指标。作为北欧参考区间项目(NORIP)的一部分,这些样本于1999年11月至2001年11月期间采集,并在参与该研究的60个实验室目前正在使用的12种不同类型的现代自动血液学仪器上进行了分析。已计算出以下指标的非参数参考区间(2.5至97.5百分位数):β-血红蛋白(女性117 - 153 g/L,男性134 - 170 g/L)、β-红细胞(女性3.94 - 5.16×10¹²/L,男性4.25 - 5.71×10¹²/L)、β-红细胞体积分数(女性0.348 - 0.459,男性0.395 - 0.500)、β-平均红细胞体积(82 - 98 fL)、红细胞平均血红蛋白含量(27.1 - 33.3 pg)、红细胞平均血红蛋白浓度(317 - 357 g/L)、β-血小板计数(女性165 - 387×10⁹/L,男性145 - 348×10⁹/L)和β-白细胞计数(3.5 - 8.8×10⁹/L)。根据标准化程序,按年龄和性别对数据进行了划分。对于大多数变量,计算出的参考区间与较旧且定义不太明确的参考区间相当吻合。女性的β-血红蛋白平均浓度每年增加0.08 g/L,男性则每年降低0.1 g/L。男性和女性的β-血红蛋白均随体重指数增加。吸烟使β-白细胞计数平均值增加1.1×10⁹/L,经常饮酒使β-平均红细胞体积平均值增加0.8 fL。总体而言,这些因素的影响较小,并未促使产生特定的参考区间。

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