Luo Xuan, Feng Lei, Bai XueJing, Zhu JiangXian, Zhao GuanCheng, Wu MengNa, Yan ZeFeng
Department of Laboratory, People's Hospital of Yuxi City, Yuxi, P.R. China.
SAGE Open Med. 2020 Jun 13;8:2050312120931334. doi: 10.1177/2050312120931334. eCollection 2020.
We aimed to establish a new reference interval of blood cell parameters by classifying and counting blood Cells of 16- to 85-year-old healthy volunteers and observing continuous changes with age.
We analyzed the blood cell parameters of 42,678 cases (men, 24,406; women, 18,272), and compared the blood cell parameters of men and women in different age groups using an independent samples t-test. Using limits of 2.5%-97.5%, a 90% confidence interval was used to develop new reference intervals.
Counts of blood cell parameters, including white blood Cells, neutrophils, lymphocytes, monocytes, eosinophils, basophils, red blood Cells, hemoglobin, hematocrit, distribution width of red blood Cells and platelets, were found to differ between men and women in different age groups. These parameters were used to establish a new reference interval of blood Cells.
The blood cell parameters of both men and women changed with increasing age. The reference interval that we established will provide more accurate basic evidence for clinical diagnosis and treatment of diseases.
通过对16至85岁健康志愿者的血细胞进行分类和计数，并观察其随年龄的持续变化，建立血细胞参数的新参考区间。
我们分析了42678例（男性24406例；女性18272例）的血细胞参数，并使用独立样本t检验比较了不同年龄组男性和女性的血细胞参数。采用2.5%-97.5%的界限，使用90%置信区间建立新的参考区间。
发现不同年龄组男性和女性的血细胞参数计数存在差异，包括白细胞、中性粒细胞、淋巴细胞、单核细胞、嗜酸性粒细胞、嗜碱性粒细胞、红细胞、血红蛋白、血细胞比容、红细胞分布宽度和血小板。这些参数用于建立血细胞的新参考区间。
男性和女性的血细胞参数均随年龄增长而变化。我们建立的参考区间将为疾病的临床诊断和治疗提供更准确的基础依据。
