新型大环内酯类抗生素的分离与结构测定

Isolation and structure determination of new macrolide antibiotics.

作者信息

Hatfield G M, Woodard R W, Son J K

机构信息

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Michigan, Ann Arbor 48109-1065.

出版信息

J Nat Prod. 1992 Jun;55(6):753-9. doi: 10.1021/np50084a008.

DOI:10.1021/np50084a008

PMID:1522418

Abstract

Three new bafilomycin-like compounds PD 118,576-A1 [1], PD 118,576-A2 [2], and PD 118,576-A3 [3] were isolated from a new soil Streptomyces species (WP 3913). The structures of PD 118,576-A1, PD 118,576-A2, and PD 118,576-A3 were elucidated on the basis of spectroscopic studies including 2D nmr.

摘要

从一种新的土壤链霉菌菌株（WP 3913）中分离出三种新的巴弗洛霉素样化合物PD 118,576-A1 [1]、PD 118,576-A2 [2]和PD 118,576-A3 [3]。基于包括二维核磁共振在内的光谱研究阐明了PD 118,576-A1、PD 118,576-A2和PD 118,576-A3的结构。