Hartmann-Petersen R, Gordon C
MRC Human Genetics Unit, Western General Hospital, Crewe Road, EH4 2XU, Edinburgh, United Kingdom.
Cell Mol Life Sci. 2004 Jul;61(13):1589-95. doi: 10.1007/s00018-004-4132-x.
The 26S proteasome is the multi-protein protease that recognizes and degrades ubiquitinylated substrates targeted for destruction by the ubiquitin pathway. In addition to the well-documented subunit organization of the 26S holoenzyme, it is clear that a number of other proteins transiently associate with the 26S complex. These transiently associated proteins confer a number of different roles such as substrate presentation, cleavage of the multi-ubiquitin chain from the protein substrate and turnover of misfolded proteins. Such activities are essential for the 26S proteasome to efficiently fulfill its intracellular function in protein degradation.
26S蛋白酶体是一种多蛋白蛋白酶，可识别并降解经泛素途径靶向破坏的泛素化底物。除了26S全酶中已充分记录的亚基组织外，显然还有许多其他蛋白质与26S复合物短暂结合。这些短暂结合的蛋白质具有多种不同作用，如底物呈递、从蛋白质底物上切割多聚泛素链以及错误折叠蛋白质的周转。这些活性对于26S蛋白酶体在蛋白质降解中有效发挥其细胞内功能至关重要。
