沙马普利辛C：一种源自海洋海绵紫德鲁伊内拉（= 紫沙海绵属）的新型细胞毒性二溴酪氨酸衍生代谢产物。
Psammaplysin C: a new cytotoxic dibromotyrosine-derived metabolite from the marine sponge Druinella (= Psammaplysilla) purpurea.
作者信息
Copp B R, Ireland C M, Barrows L R
机构信息
Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112.
出版信息
J Nat Prod. 1992 Jun;55(6):822-3. doi: 10.1021/np50084a021.
PMID:1522422
Abstract
The new, cytotoxic dibromotyrosine-derived metabolite psammaplysin C [3], in addition to the two known psammaplysins A [1] and B [2], was isolated from the marine sponge Druinella purpurea. All three compounds were found to possess moderate in vitro cytotoxicity towards the human colon tumor cell-line HCT116.
摘要
除了两种已知的沙海葵毒素A [1]和B [2]之外，还从海洋海绵紫德鲁海绵中分离出了一种新的、具有细胞毒性的二溴酪氨酸衍生代谢物沙海葵毒素C [3]。发现所有这三种化合物对人结肠肿瘤细胞系HCT116均具有中等程度的体外细胞毒性。
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