Kumar Geetika, Bernstein Jack M, Waibel Jill S, Baumann Michael A
Department of Medicine, Wright State University School of Medicine, 4100 West Third Street, Dayton, OH 45428, USA.
Am J Hematol. 2004 Jul;76(3):283-5. doi: 10.1002/ajh.20112.
Sweet's syndrome is an acute febrile neutrophilic dermatosis that is a known complication of the administration of filgrastim, a drug that causes increased neutrophil proliferation and differentiation. This complication has not previously been reported during treatment with sargramostim, a hematopoietic cytokine with activity that overlaps filgrastim. We report a case of Sweet's syndrome in association with sargramostim treatment following chemotherapy for acute myelogenous leukemia. A suspected second episode occurred after subsequent chemotherapy and sargramostim treatment. Physicians should be aware of this possible association because the signs and symptoms of Sweet's syndrome are easily mistaken as being due to infection.
斯威特综合征是一种急性发热性嗜中性皮病，是使用非格司亭（一种可导致嗜中性粒细胞增殖和分化增加的药物）已知的并发症。此前，在使用沙格司亭（一种活性与非格司亭重叠的造血细胞因子）治疗期间，尚未有该并发症的报道。我们报告了一例急性髓性白血病化疗后使用沙格司亭治疗相关的斯威特综合征病例。在随后的化疗和沙格司亭治疗后，疑似出现了第二次发作。医生应意识到这种可能的关联，因为斯威特综合征的体征和症状很容易被误认为是感染所致。
