Yang Dong-Hui, Cai Shao-Qing, Zhao Yu-Ying, Liang Hong
Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, China.
J Asian Nat Prod Res. 2004 Sep;6(3):233-6. doi: 10.1080/10286020310001608930.
Two compounds (1 and 2) have been isolated from the stem bark of Dysoxylum binectariferum (Roxb.) Hook. f. ex Bedd. Compound 1 is rohitukine [5,7-dihydroxy-2-methyl-8-[4-(3-hydroxy-1- methyl)-piperidinyl]-4H-1-benzopyran-4-one], a known compound that has anti-inflammatory and immunomodulatory activities. Compound 2 is a new alkaloid, named rohitukine N-oxide, the structure of which was elucidated on the basis of spectral evidences and comparison with the 1H NMR data of rohitukine.
从双腺杜英（Dysoxylum binectariferum (Roxb.) Hook. f. ex Bedd.）的茎皮中分离出了两种化合物（1和2）。化合物1是洛希图碱[5,7-二羟基-2-甲基-8-[4-(3-羟基-1-甲基)-哌啶基]-4H-1-苯并吡喃-4-酮]，是一种已知的具有抗炎和免疫调节活性的化合物。化合物2是一种新生物碱，命名为洛希图碱N-氧化物，其结构通过光谱证据并与洛希图碱的1H NMR数据进行比较得以阐明。
