do Nascimento Raphaela Francelino, de Sales Igor Rafael Praxedes, de Oliveira Formiga Rodrigo, Barbosa-Filho José Maria, Sobral Marianna Vieira, Tavares Josean Fechine, Diniz Margareth de Fátima Formiga Melo, Batista Leônia Maria
Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-970, PB, Brazil.
Molecules. 2015 Jan 8;20(1):929-50. doi: 10.3390/molecules20010929.
Peptic ulcer is a common disease characterized by lesions that affect the mucosa of the esophagus, stomach and/or duodenum, and may extend into the muscular layer of the mucosa. Natural products have played an important role in the process of development and discovery of new drugs, due to their wide structural diversity and present, mostly specific and selective biological activities. Among natural products the alkaloids, biologically active secondary metabolites, that can be found in plants, animals or microorganisms stand out. The alkaloids are compounds consisting of a basic nitrogen atom that may or may not be part of a heterocyclic ring. This review will describe 15 alkaloids with antiulcer activity in animal models and in vitro studies.
消化性溃疡是一种常见疾病，其特征是病变累及食管、胃和/或十二指肠黏膜，且可能延伸至黏膜肌层。天然产物因其广泛的结构多样性以及大多具有特异性和选择性的生物活性，在新药研发过程中发挥了重要作用。在天然产物中，生物碱这种可在植物、动物或微生物中发现的具有生物活性的次生代谢产物尤为突出。生物碱是由一个碱性氮原子组成的化合物，该氮原子可能是也可能不是杂环的一部分。本综述将描述在动物模型和体外研究中具有抗溃疡活性的15种生物碱。
