从臭辣树中分离得到的新型吲哚氮氧化物生物碱。

New indole N-oxide alkaloids from Evodia fargesii.

作者信息

Qu Shi-Jin, Liu Quan-Wen, Tan Chang-Heng, Jiang Shan-Hao, Zhu Da-Yuan

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, PR China.

出版信息

Planta Med. 2006 Feb;72(3):264-6. doi: 10.1055/s-2005-873195.

DOI:10.1055/s-2005-873195

PMID:16534733

Abstract

Three new indole N-oxide alkaloids, fargesine (5-hydroxy-12-methyl-10,11,12,13-tetrahydro-1 H-azepino[5,4,3-cd]indole N(12)-oxide, 1), plectocomine 12-methyl-5- O-beta-D-glucopyranoside N(12)-oxide (2), and bufotenine 5-O-beta-D-glucopyranoside N(12)-oxide (3), were isolated from the root and stem of Evodia fargesii Dode along with five known compounds. The structures of the new alkaloids were elucidated on the basis of spectroscopic analysis.

摘要

从臭辣树的根和茎中分离出三种新的吲哚氮氧化物生物碱，即吴茱萸辛（5-羟基-12-甲基-10,11,12,13-四氢-1H-氮杂环庚烷并[5,4,3-cd]吲哚N(12)-氧化物，1）、钩腺大戟碱12-甲基-5-O-β-D-吡喃葡萄糖苷N(12)-氧化物（2）和蟾蜍色胺5-O-β-D-吡喃葡萄糖苷N(12)-氧化物（3），以及五种已知化合物。通过光谱分析阐明了这些新生物碱的结构。