Jin Xu Yu
Department of Cardiothoracic Surgery, Oxford Heart Centre, John Radcliffe Hospital, Oxford, UK.
J Heart Valve Dis. 2004 May;13 Suppl 1:S70-5.
Over the past 50 years, aortic valve surgery has achieved enormous progress towards restoring durable and physiological performance of aortic valve prostheses, physiological coronary circulation, and thus the normal structure and function of the left ventricle. Throughout the entire history of aortic valve surgery, it has been clear that interactions between surgeons and physicians have not only led to improvements in operative techniques and results, but have also facilitated a better understanding of left ventricupathophysiology underlying the surgery. Embracing genetic technology with classical cardiac physiology will create a new platform to yield a more in-depth understanding of the nature of myocardial adaptation to pressure and volume changes associated with valve disease, and myocardial responses to heart valve surgery. Ultimately, this new knowledge will have a significant impact on heart valve surgery and cardiac medicine.
在过去的50年里，主动脉瓣手术在恢复主动脉瓣假体的持久和生理性能、生理性冠状动脉循环以及左心室的正常结构和功能方面取得了巨大进展。在主动脉瓣手术的整个历史中，很明显，外科医生和内科医生之间的互动不仅带来了手术技术和结果的改进，还促进了对手术背后左心室病理生理学的更好理解。将基因技术与经典心脏生理学相结合，将创建一个新的平台，以更深入地了解心肌对与瓣膜疾病相关的压力和容量变化的适应本质，以及心肌对心脏瓣膜手术的反应。最终，这些新知识将对心脏瓣膜手术和心脏医学产生重大影响。
