McCullough Jeffrey, Dodd Roger, Gilcher Ron, Murphy Scott, Sayers Merlyn
University of Minnesota, Minneapolis, Minnesota, USA.
Transfusion. 2004 Jul;44(7):1112-8. doi: 10.1111/j.1537-2995.2004.04098.x.
In January 2003, blood center personnel in the American Red Cross, Southern Region in Atlanta, noticed whitish particulate material (WPM) that had not been observed previously in several units of red blood cells (RBCs). An expert panel was formed to evaluate studies of the material and make appropriate recommendations
The expert panel reviewed information provided by several investigations and organizations. This included: background information, and experiences relating to WPM; WPM composition; factors promoting WPM formation; risk of WPM (if any) to patients; and recommendations to prevent future occurrences.
WPM is derived from blood. No data suggest that external contamination or collection set components contribute to WPM development. A major constituent of WPM is platelets (PLTs). WPM is most commonly observed in RBCs that have been subjected to a hard spin without PLT separation. WPM is rarely, if ever, observed in RBCs that have been subjected to leukoreduction.
(1) WPM is not new, can be prevented, and can be removed. (2) WPM contains PLTs, white blood cells, fibrin, and cellular debris. (3) Changes in blood handling are not necessary. (4) WPM may be more frequent when higher g forces are used in component preparation. (5) Enhanced visual inspection of blood components need not be continued. (6) It appears that WPM may not form in RBC collected using automated devices. (7) WPM did not pose a risk to patients but should be avoided.
2003年1月，位于亚特兰大的美国红十字会南部地区血液中心的工作人员注意到，在几个单位的红细胞（RBC）中出现了以前未曾见过的白色颗粒物质（WPM）。为此成立了一个专家小组，以评估对该物质的研究并提出适当建议。
专家小组审查了多项调查和组织提供的信息。这包括：背景信息，以及与WPM相关的经验；WPM的组成；促进WPM形成的因素；WPM对患者的风险（如有）；以及预防未来发生的建议。
WPM源自血液。没有数据表明外部污染或采血装置组件会导致WPM的产生。WPM的主要成分是血小板（PLT）。WPM最常见于未经血小板分离而进行强力离心的红细胞中。在经过白细胞滤除的红细胞中，极少（如果有的话）观察到WPM。
（1）WPM并非新出现的物质，可以预防且可去除。（2）WPM包含血小板、白细胞、纤维蛋白和细胞碎片。（3）无需改变血液处理方式。（4）在成分制备中使用更高的离心力时，WPM可能更常见。（5）无需继续加强对血液成分的目视检查。（6）似乎使用自动化设备采集的红细胞中可能不会形成WPM。（7）WPM对患者不构成风险，但应避免出现。
