Shrestha P, Yamada K, Higashiyama H, Takagi H, Mori M
Department of Oral and Maxillofacial Surgery, Asahi University, Gifu, Japan.
J Oral Pathol Med. 1992 Aug;21(7):314-7. doi: 10.1111/j.1600-0714.1992.tb01018.x.
The expression of epidermal growth factor receptor (EGFR) was investigated in 67 cases of odontogenic cysts and 35 cases of odontogenic tumors using monoclonal antibody to EGFR (Biomarker, Israel) to determine the presence and significance of this transmembrane growth factor receptor. The cystic epithelial cells of odontogenic cystic lesions (keratocyst 60%; primordial cyst 75%; radicular cyst 35%; and follicular cyst 47.4%) were positive to EGFR staining. Cytochemical characterization of EGFR in those cystic epithelium was cell membrane positive type as in the normal epithelium. No expression of EGFR was found in the odontogenic tumors. This diversity of EGFR represents no binding activity of EGF, or loss of EGFR in the tumor cell upon EGFR mediated growth in odontogenic tumors was suggested a different tumor cell growth factor status or microenvironment in cell proliferation mechanism at the cellular level in cysts and tumors of odontogenic origin.
使用针对表皮生长因子受体（EGFR）的单克隆抗体（以色列生物标志物公司），对67例牙源性囊肿和35例牙源性肿瘤进行研究，以确定这种跨膜生长因子受体的存在及其意义。牙源性囊性病变（角化囊肿60%；始基囊肿75%；根尖囊肿35%；滤泡囊肿47.4%）的囊性上皮细胞EGFR染色呈阳性。这些囊性上皮中EGFR的细胞化学特征与正常上皮一样为细胞膜阳性型。在牙源性肿瘤中未发现EGFR表达。EGFR的这种差异表明牙源性肿瘤中不存在表皮生长因子（EGF）的结合活性，或者在EGFR介导的生长过程中肿瘤细胞中EGFR缺失，提示在牙源性囊肿和肿瘤的细胞增殖机制中，细胞水平上存在不同的肿瘤细胞生长因子状态或微环境。
