KAI-1蛋白在牙源性囊肿中的表达。

KAI-1 protein expression in odontogenic cysts.

作者信息

Iezzi Giovanna, Piattelli Adriano, Artese Luciano, Goteri Gaia, Fioroni Massimiliano, Rubini Corrado

机构信息

Dental School, University of Chieti-Pescara, Italy.

出版信息

J Endod. 2007 Mar;33(3):235-8. doi: 10.1016/j.joen.2006.11.005.

DOI:10.1016/j.joen.2006.11.005

PMID:17320703

Abstract

The KAI-1 tumor suppressor gene is widely distributed in normal tissues and its down-regulation may be correlated with the invasive phenotype and metastases in several different epithelial tumors. The aim of the present study was an evaluation of KAI-1 expression in radicular cysts (RC), follicular cysts (FC), orthokeratinized keratocysts (OOKC), and parakeratinized keratocysts (POKC). Eighty-five odontogenic cysts, 28 RC, 22 FC, and 35 OKC (16 OOKC, 19 POKC) were selected. All the POKC were negative and only four of 16 of the OOKC were positive for KAI-1. On the contrary, all RC and FC cases were positive and immunoreactivity for KAI-1 was detected throughout all the layers of the cyst epithelium. The lack of KAI-1 expression in POKC could help to explain the differences in the clinical and pathologic behavior of OKC and, according to what has been reported for epithelial tumors, could be related to the increased aggressive behavior and invasiveness of OKC.

摘要

KAI-1肿瘤抑制基因广泛分布于正常组织中，其下调可能与几种不同上皮肿瘤的侵袭表型和转移相关。本研究的目的是评估KAI-1在根囊肿（RC）、滤泡囊肿（FC）、正角化型牙源性角化囊肿（OOKC）和不全角化型牙源性角化囊肿（POKC）中的表达。选取了85个牙源性囊肿，其中28个RC、22个FC和35个OKC（16个OOKC、19个POKC）。所有POKC均为KAI-1阴性，16个OOKC中只有4个为KAI-1阳性。相反，所有RC和FC病例均为阳性，且在囊肿上皮的所有层均检测到KAI-1免疫反应性。POKC中KAI-1表达的缺失有助于解释OKC临床和病理行为的差异，并且根据上皮肿瘤的报道，可能与OKC侵袭性增加的行为和侵袭性有关。