Nash Gerard B, Buckley Christopher D, Ed Rainger G
Division of Medical Science, The Medical School, The University of Birmingham, Birmingham B15 2TT, UK.
FEBS Lett. 2004 Jul 2;569(1-3):13-7. doi: 10.1016/j.febslet.2004.05.040.
The locations at which vascular endothelial cells recruit leukocytes during physiological or pathological inflammatory responses are influenced by direct effects of local haemodynamics on leukocyte adhesion. However, the expression of genes by endothelial cells, and their ability to respond to inflammatory cytokines also depend on the flow forces to which they are exposed. In addition, cells of the underlying stroma can modify the phenotype and responsiveness of endothelial cells, and hence their ability to recruit leukocytes. Thus, endothelial cells are plastic in their responses, and we hypothesise that the pattern of recruitment of leukocytes to tissues is critically dependent on the variable modulation of the endothelium by the local physicochemical microenvironment.
在生理或病理性炎症反应期间，血管内皮细胞募集白细胞的位置受局部血流动力学对白细胞黏附的直接影响。然而，内皮细胞的基因表达及其对炎性细胞因子的反应能力也取决于它们所承受的流动作用力。此外，下层基质的细胞可改变内皮细胞的表型和反应性，从而影响其募集白细胞的能力。因此，内皮细胞的反应具有可塑性，我们推测白细胞向组织募集的模式关键取决于局部物理化学微环境对内皮的可变调节作用。
