Parsonage Greg, Filer Andrew D, Haworth Oliver, Nash Gerard B, Rainger G Ed, Salmon Michael, Buckley Christopher D
Rheumatology Research Group, Institute of Biomedical Research, MRC Center for Immune Regulation, University of Birmingham, UK, B15 2TT.
Trends Immunol. 2005 Mar;26(3):150-6. doi: 10.1016/j.it.2004.11.014.
To navigate into and within tissues, leukocytes require guidance cues that enable them to recognize which tissues to enter and which to avoid. Such cues are partly provided at the time of extravasation from blood by an endothelial address code on the luminal surface of the vascular endothelium. Here, we review the evidence that fibroblasts help define an additional stromal address code that directs leukocyte behaviour within tissues. We examine how this stromal code regulates site-specific leukocyte accumulation, differentiation and survival in a variety of physiological stromal niches, and how the aberrant expression of components of this code in the wrong tissue at the wrong time contributes to the persistence of chronic inflammatory diseases.
为了在组织中穿行并在组织内移动，白细胞需要引导线索，以便识别进入哪些组织以及避开哪些组织。此类线索部分由血管内皮腔表面的内皮地址编码在从血液渗出时提供。在此，我们综述了成纤维细胞有助于定义另一种基质地址编码的证据，该编码指导白细胞在组织内的行为。我们研究了这种基质编码如何在各种生理基质微环境中调节位点特异性白细胞的积累、分化和存活，以及该编码的成分在错误的时间于错误的组织中异常表达如何导致慢性炎症性疾病的持续存在。
