Adhikari Suman, Nath Priyatosh, Deb Vishal Kumar, Das Niranjan, Banerjee Antara, Pathak Surajit, Duttaroy Asim K
Department of Chemistry, Govt. Degree Collage, Dharmanagar, Tripura, India.
Department of Otolaryngology/Head and Neck Surgery, Louisiana State University Health Shreveport, Shreveport, LA, United States.
Front Pharmacol. 2025 Jun 17;16:1570385. doi: 10.3389/fphar.2025.1570385. eCollection 2025.
Chalcones isolated from natural sources are the primary metabolites of numerous biologically intriguing and pharmacologically essential drugs. Chalcones' pharmacological properties are believed to result from a double bond conjugated to carbonyl functionality. This review aims to summarise the research findings, showing naturally occurring chalcones as a preferred scaffold in medicinal chemistry. Natural chalcones have an intense antimicrobial activity that targets many pathogens, including viruses, bacteria, fungi, and protozoa. Strong antibiotic qualities are exhibited by chalcones, including 4-hydroxyderricin, licochalcone A and C, isobavachalcone, and pinocembrin chalcone. Furthermore, chalcones are promising pharmacological agents for cancer treatment; they inhibit angiogenesis, decrease metastasis, and induce death in tumor cells via diverse mechanisms. Chalcones are also considered promising therapeutic agents for diabetes, neurodegenerative diseases, and cardiovascular diseases because of their anti-inflammatory and antioxidant characteristics and ability to modify enzyme functioning. This review emphasizes several aspects, such as the biosynthesis of chalcones, preparation of chalcone derivatives, isolation of chalcones, structural features of chalcones, structure-activity relationship study, the role of natural chalcones in managing various diseases and illustrates their action mechanism to control disease progression.
从天然来源分离得到的查耳酮是众多具有生物学吸引力和药理学重要性的药物的主要代谢产物。查耳酮的药理特性被认为源于与羰基官能团共轭的双键。本综述旨在总结研究结果，表明天然存在的查耳酮是药物化学中一种优选的骨架。天然查耳酮具有强烈的抗菌活性，可针对许多病原体，包括病毒、细菌、真菌和原生动物。查耳酮表现出强大的抗生素特性，包括4-羟基德里辛、甘草查耳酮A和C、异补骨脂查耳酮以及松属素查耳酮。此外，查耳酮是有前景的癌症治疗药物；它们通过多种机制抑制血管生成、减少转移并诱导肿瘤细胞死亡。由于其抗炎和抗氧化特性以及改变酶功能的能力，查耳酮也被认为是糖尿病、神经退行性疾病和心血管疾病的有前景的治疗药物。本综述强调了几个方面，如查耳酮的生物合成、查耳酮衍生物的制备、查耳酮的分离、查耳酮的结构特征、构效关系研究、天然查耳酮在管理各种疾病中的作用，并阐明了它们控制疾病进展的作用机制。
