草酰胺类作为新型NR2B选择性N-甲基-D-天冬氨酸受体拮抗剂。
Oxamides as novel NR2B selective NMDA receptor antagonists.
作者信息
Barta-Szalai Gizella, Borza István, Bozó Eva, Kiss Csilla, Agai Béla, Proszenyák Agnes, Keseru György M, Gere Anikó, Kolok Sándor, Galgóczy Kornél, Horváth Csilla, Farkas Sándor, Domány György
机构信息
Gedeon Richter Ltd, 10, PO Box 27, H-1475 Budapest, Hungary.
出版信息
Bioorg Med Chem Lett. 2004 Aug 2;14(15):3953-6. doi: 10.1016/j.bmcl.2004.05.053.
PMID:15225705
Abstract
A novel series of oxamides derived from indole-2-carboxamides was identified as potent NR2B selective NMDA receptor antagonists. Several members of this group showed good analgesic activity in the mouse formalin test.
摘要
一系列源自吲哚-2-甲酰胺的新型草酰胺被鉴定为有效的NR2B选择性NMDA受体拮抗剂。该组中的几个成员在小鼠福尔马林试验中显示出良好的镇痛活性。
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