Borza István, Kolok Sándor, Galgóczy Kornél, Gere Anikó, Horváth Csilla, Farkas Sándor, Greiner István, Domány György
Gedeon Richter Ltd, Budapest 10, PO Box 27, H-1475, Hungary.
Bioorg Med Chem Lett. 2007 Jan 15;17(2):406-9. doi: 10.1016/j.bmcl.2006.10.033. Epub 2006 Oct 17.
A novel series of kynurenic acid amides, ring-enlarged derivatives of indole-2-carboxamides, was prepared and identified as in vivo active NR2B subtype selective NMDA receptor antagonists. The synthesis and SAR studies are discussed.
制备了一系列新型犬尿氨酸酰胺，即吲哚-2-甲酰胺的扩环衍生物，并鉴定其为体内活性的NR2B亚型选择性NMDA受体拮抗剂。讨论了其合成及构效关系研究。
