Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists.
作者信息
Borza István, Kolok Sándor, Ignácz-Szendrei Györgyi, Greiner István, Tárkányi Gábor, Galgóczy Kornél, Horváth Csilla, Farkas Sándor, Domány György
机构信息
Gedeon Richter Ltd., Budapest, 10. PO Box 27, H-1475, Hungary.
出版信息
Bioorg Med Chem Lett. 2005 Dec 15;15(24):5439-41. doi: 10.1016/j.bmcl.2005.08.110. Epub 2005 Oct 5.
PMID:16213709
Abstract
A novel series of indole-2-carboxamidine derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the substituents on the indole skeleton as well as the substitution of the benzyl moiety on the biological activity of the compounds was studied. Compound 5a was po active in the formalin test in mouse.
摘要
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