Reddy Natala Srinivasa, Mallireddigari Muralidhar Reddy, Cosenza Stephen, Gumireddy Kiranmai, Bell Stanley C, Reddy E Premkumar, Reddy M V Ramana
Fels Institute for Cancer Research, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140-5101, USA.
Bioorg Med Chem Lett. 2004 Aug 2;14(15):4093-7. doi: 10.1016/j.bmcl.2004.05.016.
Synthesis of coumarin 3-(N-aryl) sulfonamides was accomplished either by Knoevenagel condensation of anilinosulfonylacetic acids with suitable salicylaldehydes or by the reaction of methyl anilinosulfonylacetates with substituted salicylaldehydes in presence of a catalytic amount of a base. All the compounds tested for antiproliferative activity in different cancer cell lines have shown GI(50) values less than 100 microM.
香豆素 3 -（N - 芳基）磺酰胺的合成可通过苯胺基磺酰基乙酸与合适的水杨醛进行克诺文纳格尔缩合反应来实现，或者通过在催化量的碱存在下，使苯胺基磺酰基乙酸甲酯与取代水杨醛反应来完成。在不同癌细胞系中测试其抗增殖活性的所有化合物的 GI(50) 值均小于 100 μM。
