Heitland A, Piatkowski A, Noah E M, Pallua N
Department of Plastic and Reconstructive Surgery, Burns Unit, RWTH, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
Burns. 2004 Aug;30(5):471-5. doi: 10.1016/j.burns.2004.01.010.
The clinical use of an artificial skin substitute (Integra) has been celebrated enthusiastically as an improvement in burn therapy over a period of more than 10 years. Many case-reports have shown the positive effects of the treatment with Integra as a skin substitute. In this study we examine the alterations of Integra-usage in Germany. Fifteen German burn centres have been interviewed respectively over a time period of 6 years with interviews in the years 1999, 2001, and 2003. The goal of this study is to focus on the problems associated with the use of artificial skin and to create a manual for Integra-therapy including indication, pre-, intra-, and postoperative treatment. Since the first Integra Users seminar in Germany in 1999 repeated interviews have been conducted with fifteen German burn centres. The collected results of the last 6 years were evaluated. These results show a change in the indication for the therapy with artificial skin towards extensive full thickness burned patients and as extended indication especially for posttraumatic reconstruction. This article gives our guidelines for the usage and handling of Integra and shows that Integra is an important reconstructive dermal substitute for the severely burned or posttraumatic patient if handled by a skilled surgeon in a correct way.
在过去十多年里，人工皮肤替代品（Integra）在临床治疗中的应用一直备受推崇，被视为烧伤治疗的一项重大进展。众多病例报告都显示了使用Integra作为皮肤替代品进行治疗的积极效果。在本研究中，我们对德国Integra的使用情况变化展开了调查。在1999年、2001年和2003年这6年时间里，我们分别对15家德国烧伤中心进行了访谈。本研究的目的在于聚焦与使用人工皮肤相关的问题，并编写一本Integra治疗手册，内容涵盖适应症、术前、术中和术后治疗。自1999年在德国举办首次Integra用户研讨会以来，我们对15家德国烧伤中心进行了多次访谈。对过去6年收集到的结果进行了评估。这些结果表明，人工皮肤治疗的适应症已转向大面积全层烧伤患者，并且作为扩展适应症，尤其用于创伤后重建。本文给出了我们关于Integra使用和处理的指导原则，并表明如果由技术娴熟的外科医生以正确方式操作，Integra对于重度烧伤或创伤后患者而言是一种重要的重建性真皮替代品。
