Benharroch D, Shemer-Avni Y, Myint Y-Y, Levy A, Mejirovsky E, Suprun I, Shendler Y, Prinsloo I, Ariad S, Rager-Zisman B, Sacks M, Gopas J
Department of Pathology, The Soroka University Medical Center, PO Box 151, Beer-Sheva 84101, Israel.
Br J Cancer. 2004 Aug 2;91(3):572-9. doi: 10.1038/sj.bjc.6601900.
The quest for an infectious agent that may account for cases of Hodgkin's disease (HD) especially in young adults has proven vain until lately. We have recently reported findings that suggested the presence of measles virus (MV) antigens and MV RNA in the tissues of patients with HD. Support for an association between MV and HD has been provided by recent epidemiological findings relating the occurrence of HD to exposure to measles in pregnancy and the perinatal period. We now present further evidence of this putative association based on immunohistochemical, reverse transcriptase-polymerase chain reaction (RT-PCR) and in situ hybridisation studies (ISH) on HD tissues. Biopsies from 82 (54.3%) of our cohort of 154 patients showed a positive immunostain with at least two of the anti-measles antibodies used. Latent membrane protein-1 immunostaining for Epstein-Barr virus was positive in 46 (31.1%) of the patients examined. Reverse transcriptase-PCR and ISH for measles RNA were positive in seven and 10 of 28 patients, respectively. Preliminary clinicopathological associations between MV and HD are noted in this study, but no causal relationship can be claimed at this stage.
探寻可能导致霍奇金淋巴瘤（HD）病例，尤其是在年轻人中发病的感染因子，直到最近都没有结果。我们最近报告了一些发现，提示HD患者组织中存在麻疹病毒（MV）抗原和MV RNA。近期的流行病学研究结果表明HD的发生与孕期及围产期接触麻疹有关，这为MV与HD之间的关联提供了支持。我们现在基于对HD组织的免疫组化、逆转录聚合酶链反应（RT-PCR）和原位杂交研究（ISH），展示这种假定关联的进一步证据。在我们154例患者队列中，82例（54.3%）的活检组织对至少两种所用抗麻疹抗体呈免疫染色阳性。在接受检查的患者中，46例（31.1%）对爱泼斯坦-巴尔病毒的潜伏膜蛋白-1免疫染色呈阳性。在28例患者中，分别有7例和10例的麻疹RNA逆转录-PCR和ISH呈阳性。本研究注意到MV与HD之间初步的临床病理关联，但现阶段尚不能断言存在因果关系。
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